PMS or premenstrual syndrome include symptoms such as depression, tension, headache breast tenderness, water retention, bloating low energy and irritability. Vitamin B6 and magnesium and zinc may useful to reduce breast tenderness and swelling as they play a role in making prostaglandins. Gamma-linolenic acid, an essential fatty acid found in evening primrose oil and borage oils can also help reduce PMS symptoms. Some women with more pronounced symptoms cannot be corrected by diet and supplements alone. This imbalance is caused by estrogen dominance and relative lack of progesterone.

Estradiol is the most potent estrogen. There is a fine balance between the female hormones estrogen and progesterone, maintaining a complementary and antagonistic effect to keep the body in homeostasis.

Estrogen is a feminizing hormone. They shape the female body; enlarge breast and pelvis and increases blood supply to the skin

Progesterone prepares the uterus for implantation of a fertilized egg cell. It plays an essential role of pregnancy.

Daily secretion in young healthy women is about 60-200ug and progesterone secretion 1-2mg day in the first half of menstrual cycle and 20-40 milligram in the second half.